Cholesterol Esterases. VII. Hydrolysis of Branched Chain Esters by Pancreatic Cholesterol Esterase.

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Abstract
A series of branched chain fatty acid esters of cholesterol were syn-thesized and the characteristics of each determined. The hydrolysis of these esters and corresponding n-acid esters by pancreatic cholesterol esterase was studied under standard conditions. The branched chain acid esters were hydrolyzed at lower rates than corresponding n-acid esters. The closer the location of the branch to the ester bond the greater the depression in activity. Esters with ethyl groups on carbon 2 were hydrolyzed at a slower rate than those with methyl groups at this location.
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