Brominated Indole Alkaloids from the Marine Tunicate Pseudodistoma arborescens
- 1 January 1993
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 56 (1) , 99-104
- https://doi.org/10.1021/np50091a014
Abstract
Chemical investigation of the cytotoxic CH2Cl2-soluble extract of the marine tunicate Pseudodistoma arborescens led to the isolation of four brominated indole alkaloids, arborescidines A [1], B [2], C [3], and D [4], which were characterized by their spectral data, especially 2D nmr. Only arborescidine D [4] showed moderate activity (IC50 3 micrograms/ml) in vitro against the growth of KB human buccal carbinoma cells.Keywords
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