A New Thienodiazepine, Brotizolam, for the Treatment of Insomnia

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Abstract
A double-blind crossover study was carried out in twenty hospitalized inpatients who, apart from their primary diagnosis, suffered from non-psychiatric chronic insomnia. The patients received 0·5 mg brotizolam or 30 mg flurazepam for a 2-week period. Both drugs improved the induction and continuity of sleep, and increased the total sleep time, although better results were observed with brotizolam in all the parameters studied.

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