THE POWER OF IDENTITY-BY-STATE METHODS FOR LINKAGE ANALYSIS
- 1 February 1990
- journal article
- research article
- Vol. 46 (2) , 254-265
Abstract
The affected-sib-pair method has been widely utilized for mapping. This methodology is aimed at mapping complex traits which have been observed to be familial but for which Mendelian segregation, even after allowing for partial penetrance, is not apparent. Indications of linkage are based on the observation of nonrandom segregation at a marker locus in two affected siblings. We extend this methodology to more distant genetic relationships and examined the power of identity-by-state methods for mapping when marker information is only available on pairs of affected relatives. The power depends on the polymorphism of the marker, the probability of identity by descent at the trait locus, and the recombination fraction between the trait and the marker loci.This publication has 14 references indexed in Scilit:
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