Effect of exogenous d-aldosterone on heat acclimatization in man.

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Abstract
In a crossover design, 6 unacclimatized men received 1.0 mg of d-aldosterone daily for 3 days before and the first 6 days of a heat exposure (120/80 F dry/wet bulb) during which they marched continuously for 90 min. With aldosterone before the heat, there was the expected urine Na retention and K excretion and weight gain without blood pressure elevation. During the heat, blood pressure, body weight, electrocardiograms, and serum, urine, and sweat electrolytes were not significantly different with or without aldosterone. With aldosterone the men could march longer during the first 3 days (P <.05), had lower pulse rates during the first 4 days (P<.035), and had lower rectal temperatures during the first 5 days (P<.01). However, no shortening of total acclimatization time was seen.

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