Fulminant Hepatitis E in Japan

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Abstract
Hepatitis E virus (HEV) is the leading cause of water-borne epidemics of hepatitis in many developing countries in Asia and Africa, where high mortality has been reported among infected pregnant women.1 Recently, it has become clear that sporadic hepatitis E occurs in persons in industrialized countries who have no evidence of exposure to HEV strains from countries where the infection is endemic.1-3 However, the contribution of HEV to the development of fulminant hepatitis in industrialized nations is unclear.