Halothane Requirement during Pregnancy and Lactation in Rats

Publisher Website
Google Scholar
Abstract
Near-term pregnancy is associated with a decrease in the minimum alveolar concentration (MAC) for halothane in ewes. Although increased progesterone levels might account for this change, a correlation between MAC and the known variations of progesterone levels which occur throughout gestation and the postpartum period was not performed. MAC for halothane was determined in nonpregnant, 10 days pregnant, term and postpartum, lactating rats. MAC values were significantly decreased by 19% on the 10th day of pregnancy and by 16% at term, but they returned to control values 5 days postpartum. These changes did not correlate with the known changes in progesterone levels during pregnancy and lactation and apparently progesterone is not responsible for the reduction in halothane MAC.

This publication has 1 reference indexed in Scilit: