Is There α-Adrenergic Blockade and/or Serotonergic Blockade During Chronic Ketanserin Treatment?

Publisher Website
Google Scholar
Abstract
Drugs are not absolute in their specificity; the mechanisms by which many agents reduce blood pressure remain disputed. Ketanserin has been shown to have both 5-HT2-serotonergic and alpha 1-adrenergic antagonist activity. Its pharmacological profile makes its designation as a serotonergic antagonist appropriate; however, the relative contributions of at least these two, and perhaps other, mechanisms to the hypotensive effect of ketanserin during long-term oral treatment remain obscure.

This publication has 0 references indexed in Scilit: