Cellular mosaicism in the methylation and expression of hemizygous loci in the mouse.
Open Access
- 1 November 1989
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 3 (11) , 1669-1676
- https://doi.org/10.1101/gad.3.11.1669
Abstract
Proposed models for the inheritance of locus-specific methylation phenotypes in somatic cells include those in which there is stable inheritance of a methylation pattern such that all cells contain a similarly methylated locus, as well as models in which the inheritance of methylation can be variable. We investigated these possibilities by examining the methylation and expression of hemizygous loci in the mouse. Our results demonstrate that differences in both methylation and expression can exist between apparently identical cells and that such mosaicism is genetically controlled.This publication has 26 references indexed in Scilit:
- Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes.Genes & Development, 1988
- Conversion of Normal Behavior to Shiverer by Myelin Basic Protein Antisense cDNA in Transgenic MiceScience, 1988
- The Inheritance of Epigenetic DefectsScience, 1987
- Allele-specific methylation of the human c-Ha-ras-1 geneCell, 1987
- Degree of methylation of transgenes is dependent on gamete of originNature, 1987
- Genomic imprinting determines methylation of parental alleles in transgenic miceNature, 1987
- High frequency germline acquisition of ecotropic MuLV proviruses in SWR/J-RF/J hybrid miceCell, 1985
- DNA METHYLATION AND GENE ACTIVITYAnnual Review of Biochemistry, 1983
- The somatic replication of DNA methylationCell, 1981
- Rare Bases in Animal DNANature, 1970