RADIOPHARMACEUTICALS .27. F-18-LABELED 2-DEOXY-2-FLUORO-D-GLUCOSE AS A RADIOPHARMACEUTICAL FOR MEASURING REGIONAL MYOCARDIAL GLUCOSE-METABOLISM INVIVO - TISSUE DISTRIBUTION AND IMAGING STUDIES IN ANIMALS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (10) , 990-996
Abstract
18F-2-deoxy-2-fluoro-D-glucose (18FDG) is rapidly extracted by the mouse heart, and the radioactivity in heart (3-4%/organ) remains relatively constant for 2 h post injection. Brain uptake (2-3%/organ) remained relatively constant throughout the time course of the study. Liver, lungs, kidneys, small intestine and blood all showed a rapid clearance of radioactivity after a 18FDG injection. At 120 min the heart-to-lung ratio was 12 and heart-to-liver ratio was 32. Urinary excretion of activity was .apprx. 16% of the injected dose at 60 min. The radioactivity uptake by dog heart following the i.v. 18FDG administration was 2.8-4.1% at 60 min and 2.4% at 135 min; it was regionally distributed, the areas of highest activity being the left ventricle and interventricular septum. Brain activity was 2.1-3.5% at 120 min, with a ratio of gray matter-to-white matter of 2-3:1. Urinary excretion in dogs was 16% and 50% of the injected dose at 60 and 135 min. The chemical form of the activity in the urine, although unidentified, was not 18F-. Cross-sectional images of the myocardium of the dog after i.v. injection of 18FDG were obtained using emission tomography.