Cardiac output in man in rest and work during and after acclimatization to 3,800 m.

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Abstract
Cardiac output (Q) during rest and work was determined by a CO2 method at an altitude of 3,800 m. The change of Q was followed on 3 subjects during the first 8-12 days at altitude, and in rest and 2 work levels in 5 subjects after 3-4 weeks of acclimatization. Q was increased on the first day at 3,800 m to a maximum in 2 young subjects, and decreased the following days to values slightly lower than at sea level. In the old subject no change of Q was found in rest while in work a slow increase was seen the first 3 days to a plateau, which was maintained until the last day at 3,800 m. After 3-4 weeks of acclimatization it was found that Q was slightly below its sea level values both in rest and at the 2 work levels. The change of Q is discussed in relation to changes in other circulatory functions and in blood characteristics.

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