SPECIFIC ANTIBODY RESPONSE TO THE MYCOBACTERIAL 65 kDa STRESS PROTEIN IN ANKYLOSING SPONDYLITIS AND RHEUMATOID ARTHRITIS
Open Access
- 1 December 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 29 (6) , 426-429
- https://doi.org/10.1093/rheumatology/29.6.426
Abstract
Immune responses to conserved, immunogenic homologues of the mycobacterial 65 kDa stress protein (SF65) have been implicated in inflammatory arthritis. Serum anti-SP65 was measured in AS, RA and healthy controls using an indirect enzyme immunoassay with recombinant SP65. IgA anti-SP65 was elevated in 19 of 59 AS patients, but the elevation in median level was not statistically significant. Anti-SP65 of all isotypes was increased in RA, but achieved significance (P<0.01) for IgA only. Adjusting specific antibody results for elevations in total serum Ig levels reduced AS and RA anti SP65 to near normal levels, suggesting that a major component of the increased anti-SP65 may be secondary to polyclonal activation.Keywords
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