Relaxation times of choline, creatine and N‐acetyl aspartate in human cerebral white matter at 1.5 T
- 28 February 2002
- journal article
- clinical trial
- Published by Wiley in NMR in Biomedicine
- Vol. 15 (3) , 215-221
- https://doi.org/10.1002/nbm.762
Abstract
Several studies have investigated the T1 and T2 relaxation time of choline, creatine and N‐acetyl aspartate in cerebral white matter in normal human subjects. However, these studies demonstrate a large variation in T1 and T2 values. In the present study, relaxation times of choline, creatine and N‐acetyl aspartate were determined in cerebral white matter in 15 control subjects (age 21 ± 2 y, mean ± SD) at 1.5 T. Using PRESS, seven or eight data points were obtained to fit the T1 and T2 relaxation curves to, respectively. The mean voxel size was 14 cm3. The T1 relaxation times of choline, creatine and N‐acetyl aspartate were 1091 ± 132 (mean ± SD), 1363 ± 137 and 1276 ± 132 ms. The T2 relaxation times were 352 ± 52, 219 ± 29 and 336 ± 46 ms, respectively. Copyright © 2002 John Wiley & Sons, Ltd.Keywords
This publication has 19 references indexed in Scilit:
- Quantitative localized 1H MR spectroscopy for clinical useProgress in Nuclear Magnetic Resonance Spectroscopy, 1997
- Quantitative proton MR spectroscopic imaging of the human brainMagnetic Resonance in Medicine, 1996
- Quantification of metabolites from single-voxelin vivo 1H NMR data of normal human brain by means of time-domain data analysisMagnetic Resonance Materials in Physics, Biology and Medicine, 1995
- Determination of proton metabolite concentrations and relaxation parameters in normal human brain and intracranial tumoursNMR in Biomedicine, 1995
- Absolute Quantitation of Brain *H Nuclear Magnetic Resonance SpectraInvestigative Radiology, 1995
- Absolute quantitative proton NMR spectroscopy based on the amplitude of the local water suppression pulse. Quantification of brain water and metabolitesNMR in Biomedicine, 1994
- Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration referenceNMR in Biomedicine, 1993
- Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolitesMagnetic Resonance in Medicine, 1989
- Accurate quantification of in vivo31P NMR signals using the variable projection method and prior knowledgeMagnetic Resonance in Medicine, 1988