Infusion of Vasoactive Intestinal Polypeptide in Man: Pharmacokinetics and Effect on Gastric Acid Secretion

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Abstract
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in 6 healthy volunteers. A background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise i.v. infusions in doses of 0.5, 0.9 and 2.7 .mu.g/kg-h, each dose being given for 1 h. Mean plasma VIP concentrations rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the VIP infusions. No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone and no duodenogastric reflux was registered. Serum gastrin concentrations were unaltered during VIP infusion. Elimination of VIP was biexponential with half-lives of 2 and 21 min, respectively. Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg.