N‐methyl‐D‐aspartate antagonists: Ready for clinical trial in brain ischemia?
- 1 April 1989
- journal article
- clinical trial
- Published by Wiley in Annals of Neurology
- Vol. 25 (4) , 398-403
- https://doi.org/10.1002/ana.410250412
Abstract
Antagonists of the N‐methyl‐D‐aspartate (NMDA) subclass of glutamate receptors may offer a new approach for the treatment of ischemic brain injury. This strategy is supported by a well‐developed scientific foundation and encouraging results in a variety of in vivo and in vitro experimental models. Several specific antagonists, including MK‐801, dextrorphan, dextromethorphan, and ketamine, have already been used at low doses in humans for other indications and are potential candidates for Phase I clinical trials.Keywords
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