Tissue injury in neutrophilic inflammation
- 1 October 1997
- journal article
- review article
- Published by Springer Nature in Inflammation Research
- Vol. 46 (10) , 382-391
- https://doi.org/10.1007/s000110050208
Abstract
The exudation of neutrophils is the hallmark of a form of inflammatory response occurring after tissue colonization by invading bacteria or as an expression of various non-infectious diseases. All these diseases are characterized by a high risk of developing irreversible tissue injury. Neutrophil-endothelium interactions, activation-induced functional and structural changes of responding neutrophils, regulatory systems of neutrophil function, and oxidative-proteolytic pathways responsible for histotoxicity are reviewed here. Finally, perspectives for rational approaches to handle the development of tissue injury during neutrophilic inflammation are considered.Keywords
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