The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.
- 1 June 1994
- journal article
- review article
- Published by BMJ in Journal of Medical Genetics
- Vol. 31 (6) , 448-452
- https://doi.org/10.1136/jmg.31.6.448
Abstract
A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.Keywords
This publication has 10 references indexed in Scilit:
- Heterogeneity of subcellular localization of p53 protein in human glioblastomas.1994
- Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors.1993
- Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.1993
- Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosomeNature Genetics, 1992
- Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients.1992
- Loss of heterozygosity, chromosome 7q, and breast cancerThe Lancet, 1992
- Loss of heterozygosity on chromosome 7q and aggressive primary breast cancerThe Lancet, 1992
- p53 germline mutations in Li-Fraumeni syndromeThe Lancet, 1991
- Allelotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q.1991
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences, 1971