Teratogenic Action of a Hypocaloric Diet and Small Doses of Cortisone.
- 1 July 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 104 (3) , 518-520
- https://doi.org/10.3181/00379727-104-25895
Abstract
Two relatively small doses of cortisone acetate administered to pregnant mice caused 1.4 and 12.0% cleft palate, respectively, in the offspring. A hypocaloric diet, consisting of about 40% of ad lib. daily intake, given during middle 3d of pregnancy, produced 5.6%, cleft palate. The doses of cortisone plus the restricted diet caused 36.8 and 50.79% cleft palate, respectively. These results are discussed.Keywords
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