Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture

2 December 2004

journal article
Published by Royal Society of Chemistry (RSC) in Chemical Communications

No. 4,p. 447-449
https://doi.org/10.1039/b413435d

Abstract

The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.

Keywords

AGENT DOXORUBICIN
CHEMOTHERAPEUTIC AGENT
COVALENTLY BOUND
SHOCK PROTEIN
ANTITUMOR AGENT
GENETICALLY MODIFIED
PROTEIN CAGE
MODIFIED SMALL
DEPENDENT MANNER

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