MICRONUCLEUS TEST OF MOFEZOLAC (N-22)
- 1 January 1990
- journal article
- Published by Japanese Society of Toxicology in The Journal of Toxicological Sciences
- Vol. 15 (Supplement) , 253-260
- https://doi.org/10.2131/jts.15.supplementii_253
Abstract
A micronucleus test using BDF1 male mice was conducted in order to evaluate the in vivo mutagenicity of mofezolac (N-22). N-22 was orally administered at doses of 75, 150, 300 and 600 mg/kg, with a sampling time of 24 hr. The frequency of polychromatic erythrocytes with micronuclei was 0.07-0.08% in the groups treated with N-22 and did not differ markedly from that of the vehicle control (0.13%). The present study indicates that N-22 has no in vivo mutagenic properties.Keywords
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