Curtius Rearrangement of ω-Azido Acid Chlorides: Access to the Corresponding ω-Azido Substituted Amines and Carbamates, Useful Building Blocks for Polyamine Syntheses
- 1 April 1996
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1996 (04) , 483-487
- https://doi.org/10.1055/s-1996-4438
Abstract
Treatment of ω-azido acid chlorides with trimethylsilyl azide affords ω-azido isocyanates which can be easily converted in good yields to the corresponding ω-azidoamines or ω-azidocarbamates. 1,3- and 1,4-Diamine dihydrochlorides can then be prepared by catalytic hydrogenation or reductive alkylation with an organodichloroborane.Keywords
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