No sex difference in mutations rates of Duchenne muscular dystrophy.
Open Access
- 1 April 1980
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 17 (2) , 106-111
- https://doi.org/10.1136/jmg.17.2.106
Abstract
Segregation analysis was performed to evaluate possible differences in mutation rates in man. It was based on 514 males with Duchenne type muscular dystrophy (DMD) from five of nineteen hospitals for muscular disease in Japan. The estimated proportion of sporadic cases (new mutations) was 0.29 +/- 0.046, which is in excellent agreement with the expected 0.333 if there is no sex difference in mutation rates. The rate of mutation was estimated to be 6.3 X 10(-5) per generation. The incidence and prevalence rates among males were estimated to be 217 X 10(-6) and 49.9 X 10(-6), respectively.This publication has 13 references indexed in Scilit:
- Systemic Membrane Defect in the Proximal Muscular DystrophiesNew England Journal of Medicine, 1978
- Estimation of proportion of new mutants among cases of Duchenne muscular dystrophy.Journal of Medical Genetics, 1978
- Effects of reproductive compensation and genetic drift on X-linked lethals.1978
- A two-locus selection hypothesis for Duchenne Muscular DystrophyTheoretical Population Biology, 1977
- Pedigree testing in duchenne muscular dystrophyAnnals of Neurology, 1977
- The incidence of Duchenne muscular dystrophy in the South East of ScotlandClinical Genetics, 1977
- Mutation in Duchenne Muscular DystrophyNew England Journal of Medicine, 1976
- Spontaneous Mutation in ManPublished by Springer Nature ,1975
- Genetic-epidemiological studies in progressive muscular dystrophy.Journal of Medical Genetics, 1971
- The rate of spontaneous mutation of a human geneJournal of Genetics, 1935