THE CLINICAL spectrum of trisomy-18 syndrome has now been sufficiently characterized1so that this condition may be suspected before chromosome analysis is carried out. The dermatoglyphic pattern is also highly characteristic. In all but one case in which the fingerprints were reported, an increased number of arches were noted.2 We report here the case of an infant with both clinical and dermatoglyphic stigmata of trisomy18syndrome who was found to have a normal karyotype. Report of a Case The patient was a white female infant born after a 37-week pregnancy to a 23-year-old mother and 36-year-old father. The mother was overweight at the beginning of her pregnancy and was placed on a diet at the onset. She gained only 3 lb (1.3 kg) in contrast to the 30-lb (13.6 kg) weight gain she had with her first pregnancy. From the second month of pregnancy, she took 7 1/2