Cell‐cell interactions in regulating osteogenesis and osteoblast function
- 1 March 2005
- journal article
- review article
- Published by Wiley in Birth Defects Research Part C: Embryo Today: Reviews
- Vol. 75 (1) , 72-80
- https://doi.org/10.1002/bdrc.20034
Abstract
Endochondral bone formation requires an elaborate interplay among autocrine, paracrine, and endocrine signals, positional cues, and cell‐cell contacts to mediate the complex three‐dimensional architecture and function of the skeleton. Embryonic bone development occurs by migration, aggregation, and condensation of immature mesenchymal progenitor cells to form the cartilaginous anlage. Upon vascular invasion, the cartilaginous scaffold is colonized and subsequently mineralized by osteoblasts. Likewise, bone remodeling in the adult skeleton is a dynamic process that requires coordinated cellular activities among osteoblasts, osteocytes, and osteoclasts to maintain bone homeostasis. This review examines the role of cell‐cell interactions mediated by adherens junctions formed by cadherins and communicative gap junctions formed by connexins in regulating bone development and osteogenic function. Birth Defects Research (Part C) 75:72–80, 2005.Keywords
This publication has 98 references indexed in Scilit:
- N‐cadherin is not essential for limb mesenchymal chondrogenesisDevelopmental Dynamics, 2004
- Gene expression alterations in connexin null mice extend beyond the gap junctionNeurochemistry International, 2004
- Expression of Gja1 correlates with the phenotype observed in oculodentodigital syndrome/type III syndactylyJournal of Medical Genetics, 2004
- Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transductionBiochemical and Biophysical Research Communications, 2003
- Cx32 Formation and/or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell LineExperimental Cell Research, 2002
- Expression of the Receptor Protein-tyrosine Phosphatase, PTPμ, Restores E-cadherin-dependent Adhesion in Human Prostate Carcinoma CellsPublished by Elsevier ,2002
- Targeted Disruption of Cadherin-11 Leads to a Reduction in Bone Density in Calvaria and Long Bone MetaphysesJournal of Bone and Mineral Research, 2001
- A Role for N-Cadherin in the Development of the Differentiated Osteoblastic PhenotypeJournal of Bone and Mineral Research, 2000
- Human Osteoblasts Express a Repertoire of Cadherins, Which Are Critical for BMP-2–Induced Osteogenic DifferentiationJournal of Bone and Mineral Research, 1998
- Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43.The Journal of cell biology, 1995