Determination of Drug Polymorphs by Laser Raman Spectroscopy. I. Ampicillin and Griseofulvin
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 3 (5) , 451-458
- https://doi.org/10.3109/03639047709055624
Abstract
Raman spectroscopy of the lattice vibrations (phonons) is used to distinguish among various crystal forms of ampicillin and griseofulvin. The two anhydrous polymorphs of ampicillin and the trihydrate are all distinguishable. Griseofulvin sol-vates with benzene and chloroform were studied. The spectra suggest that the griseofulvin lattice structure expands to accept chloroform, but that the benzene solvate has a different crystal structure.This publication has 8 references indexed in Scilit:
- Raman investigation of phase transition in octafluoronaphthalene crystalsChemical Physics Letters, 1977
- Studies on methods of particle size reduction of medicinal compounds. VI. Solvate formation of griseofulvin with benzene and dioxane.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical ApplicationsJournal of Pharmaceutical Sciences, 1975
- Spectroscopic evidence for a continuous change in molecular and crystal structure: deformation of biphenyl in the low temperature solidChemical Physics Letters, 1974
- Phonon Raman spectra, molecular motions, and phase transitions of dimethylacetylene crystalChemical Physics Letters, 1973
- Dehydration of Crystalline Theophylline Monohydrate and Ampicillin TrihydrateJournal of Pharmaceutical Sciences, 1973
- Pharmaceutical Applications of PolymorphismJournal of Pharmaceutical Sciences, 1969
- Studies on the Method of Size Reduction of Medicinal Compounds. III. Size Reduction of Griseofulvin by Solvation and Desolvation Method using Chloroform. (3)CHEMICAL & PHARMACEUTICAL BULLETIN, 1968