Successful Treatment of Cerebral Aspergillosis with a High Oral Dose of Itraconazole after Excisional Surgery.
- 1 January 1999
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 38 (10) , 829-832
- https://doi.org/10.2169/internalmedicine.38.829
Abstract
We report a case of cerebral aspergillosis which originated from the sphenoid sinus, and involved a progressive decrease of visual acuity. The neurological signs indicated a cavernous sinus invasion. After extensive intracranial surgery we treated the residual aspergillosis with a high oral dose of itraconazole (800 mg/d for 4 months, followed by 400 mg/d for 5 months). The neurological impairments of the patient gradually subsided with the resolution of the fungal lesion shown on MRI. The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults).(Internal Medicine 38: 829-832, 1999)Keywords
This publication has 0 references indexed in Scilit: