A Rac1/Phosphatidylinositol 3-Kinase/Akt3 Anti-apoptotic Pathway, Triggered by AlsinLF, the Product of the ALS2 Gene, Antagonizes Cu/Zn-superoxide Dismutase (SOD1) Mutant-induced Motoneuronal Cell Death
Open Access
- 1 February 2005
- journal article
- Published by Elsevier
- Vol. 280 (6) , 4532-4543
- https://doi.org/10.1074/jbc.m410508200
Abstract
No abstract availableKeywords
This publication has 57 references indexed in Scilit:
- PI3K/Akt and apoptosis: size mattersOncogene, 2003
- Structural Basis for the Signaling Specificity of RhoG and Rac1 GTPasesPublished by Elsevier ,2003
- The first nonsense mutation in alsin results in a homogeneous phenotype of infantile‐onset ascending spastic paralysis with bulbar involvement in two siblingsClinical Genetics, 2003
- An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindredAnnals of Neurology, 2002
- Rho GTPases in cell biologyNature, 2002
- Infantile-Onset Ascending Hereditary Spastic Paralysis Is Associated with Mutations in the Alsin GeneAmerican Journal of Human Genetics, 2002
- Rac Activation Induces NADPH Oxidase Activity in Transgenic COS Cells, and the Level of Superoxide Production Is Exchange Factor-dependentJournal of Biological Chemistry, 2002
- Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and FasJournal of Biological Chemistry, 2000
- Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathwayOncogene, 1998
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisNature, 1993