INTERACTION OF IOPANOIC AND IOPHENOXIC ACIDS WITH HUMAN-SERUM ALBUMIN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (1) , 119-127
Abstract
Iopanoic and iophenoxic acids [biliary contrast agents] are strongly bound to human serum albumin, as revealed from ultracentrifugation experiments. About 2 or 3 high affinity binding sites were found for both drugs. Within the concentration range investigated, iopanoic acid is bound more strongly than iophenoxic acid. The binding to only 1 of the high affinity binding sites produces extrinsic Cotton effects. Further saturation of the high affinity binding sites decreases the extrinsic Cotton effects, possibly due to a binding induced change of the protein conformation.

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