Enhancement of Systemic and Pulmonary Vasoconstriction by beta-Amyloid Peptides and its Suppression by Vasoactive Intestinal Peptide
- 1 December 1998
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 865 (1 VIP, PAC) , 582-585
- https://doi.org/10.1111/j.1749-6632.1998.tb11240.x
Abstract
(1) A beta peptides potentiate vasoconstriction, caused by norepinephrine, and possibly other endogenous vasoconstrictors. If this potentiation occurs in the cerebral circulation, close to sites of A beta deposition in AD brains, the enhanced vasoconstriction could result in neuronal ischemia and death. (2) By neutralizing this deleterious effect of A beta, and through other neuroprotective mechanisms, VIP may provide an important defense against neuronal loss in AD.Keywords
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