Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man

Abstract
The acute effects of hyperinsulinemia on androgen homeostasis and a possible association of androgens to insulin sensitivity, serum lipids and lipoproteins and to lipid oxidation were examined in 19 healthy males (27 ± 1 yrs, body mass index 24 ± 1 kg/m2). In each subject, a 240 min euglycemic hyperinsulinemic clamp was performed and glucose and lipid oxidation were determined by indirect calorimetry. During hyperinsulinemia serum sex hormone-binding globulin (SHBG) concentration decreased by 5% (PPPr= −0·54, Pr=0·59, Pr=0·47, Pr=0·61, Pr=0·62, Pr=0·58, PJournal of Endocrinology (1995) 146, 63–69

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