Lymphocytic thyroiditis with spontaneously resolving hyperthyroidism and subacute thyroiditis. Long-term follow-up

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Abstract
In a 1-15 yr follow-up of 124 patients with a history of subacute thyroiditis (SAT) without and with spontaneously resolving hyperthyroidism (SRH) only 3 cases of thyroid disease probably unrelated to the original episode of thyroiditis were found. Of the 54 patients with a history of lymphocytic thyroiditis (LT) with SRH (LT-SRH), 26 patients had thyroid disease (3 with hypothyroidism and 23 with goiters). Antithyroid antibodies were present in 32% (8/25) of the LT-SRH group and in less than 10% (5/60) of the other 3 groups. The basal TSH levels were substantially increased in the LT-SRH group only, and the response of TSH to 200 .MU.g protirelin was augmented in both SAT-SRH and LT-SRH groups. SAT and SAT-SRH apparently are transient thyroid diseases rarely leading to permanent thyroid disease, although some loss of thyroid reserve may occur. LT-SRH is a persistent progressive disease similar to or the same as chronic LT, in which goiter formation and thyroid failure are a natural course.

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