Spermine and thermine conjugates of cholic acid condense DNA,but lithocholic acid polyamine conjugates do so more efficiently
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 18,p. 2035-2036
- https://doi.org/10.1039/a804924f
Abstract
Polyamine amides have been prepared from cholic and lithocholic acid by acylation of tri-Boc protected spermine and thermine and their binding affinities for calf thymus DNA were determined using an ethidium bromide fluorescence quenching assay; these polyamine amides are models for lipoplex formation with respect to gene delivery (lipofection), a key first step in gene therapy.Keywords
This publication has 0 references indexed in Scilit: