Population Pharmacokinetics of Caffeine in Neonates and Young Infants
- 1 June 1996
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 18 (3) , 245-253
- https://doi.org/10.1097/00007691-199606000-00005
Abstract
The population pharmacokinetics of caffeine were investigated in 60 neonates and young infants using data collected during routine therapeutic drug monitoring. Clearance was influenced by body weight and postnatal age, and increased in the presence of dexamethasone. No clinical factors were identified that influenced volume of distribution. The population pharmacokinetic parameter estimates were then tested prospectively in a further 20 neonates. Although they produced unbiased results, the dexamethasone effect could not be identified. A final analysis using all 80 patients found clearance (L/day) = 0.14 x weight (kg) + 0.0024 x postnatal age (days) (+/- 20%) and volume of distribution = 0.82 L (+/- 24%). Simulations based on these results indicated that the current dosage guidelines of 20 mg/kg loading dose of caffeine citrate followed by a 5 mg/kg/day maintenance dose should achieve concentrations within the traditional target range in > 70% of neonates.Keywords
This publication has 14 references indexed in Scilit:
- Caffeine or theophylline for neonatal apnoea?Archives of Disease in Childhood, 1992
- Netilmicin in the neonate: Population pharmacokinetic analysis and dosing recommendationsClinical Pharmacology & Therapeutics, 1991
- Population Pharmacokinetics of Rectal Theophylline in NeonatesTherapeutic Drug Monitoring, 1991
- The population pharmacokinetics of theophylline in neonates and young infantsJournal of Pharmacokinetics and Biopharmaceutics, 1989
- Oral theophylline and diuretics improve pulmonary mechanics in infants with bronchopulmonary dysplasiaThe Journal of Pediatrics, 1987
- Effect of caffeine on pneumogram and apnoea of infancy.Archives of Disease in Childhood, 1986
- Successful extubation of infants with respiratory distress syndrome using aminophyllineThe Journal of Pediatrics, 1983
- Pharmacokinetic aspects of caffeine in premature infants with apnoeaEuropean Journal of Clinical Pharmacology, 1982
- Pharmacokinetic profile of caffeine in the premature newborn infant with apneaThe Journal of Pediatrics, 1979
- Estimation of population characteristics of pharmacokinetic parameters from routine clinical dataJournal of Pharmacokinetics and Biopharmaceutics, 1977