Two Melanesian Antisera Reacting with SsU Components

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Abstract
Two different [human] Melanesian antibodies demonstrated, by blocking tests and their reaction patterns, steric interaction of S, s and U components. The antigen(s) detected, designated UX and UZ, may represent differing conformations, genetically determined, of certain U, S and s structures. Of 1000 Caucasian blood samples, 3 had very marked enhancement of UX. Family studies are presented. In 1 such blood sample, abnormal steric interation of D with s and U was indicated. Melanesian population studies show that UX and UZ are among the antigens depressed in recessive ovalocytosis. The linkage disequilibria affecting MNSs and SsUZ are interrelated, the associations being of SUZ with Caucasian M and Melanesian N.