Oligonucleotide Conjugates as Potential Antisense Drugs with Improved Uptake, Biodistribution, Targeted Delivery, and Mechanism of Action
- 1 April 2002
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antisense and Nucleic Acid Drug Development
- Vol. 12 (2) , 103-128
- https://doi.org/10.1089/108729002760070849
Abstract
This review summarizes the effect of conjugating small molecules and large biomacromolecules to antisense oligonucleotides to improve their therapeutic potential. In many cases, favorable changes in pharmacokinetic and pharmacodynamic properties were observed. Opportunities exist to change the terminating mechanism of antisense action or to enhance the RNase H mode of action via conjugate formation.Keywords
This publication has 112 references indexed in Scilit:
- Efficient Hydrolysis of RNA by a PNA - Diethylenetriamine AdductAngewandte Chemie International Edition in English, 2000
- Synthetic Oligonucleotide Combinatorial Libraries. 3. Synthesis of PolyamevonucleosidesNucleosides and Nucleotides, 1999
- Biological Properties of Antisense Oligonucleotides Conjugated to Different High-Molecular Mass Poly(Ethylen Glycols)Nucleosides and Nucleotides, 1999
- The Cytotoxicity of Anti-PAI-I Oligonucleotides and Their ConjugatesNucleosides and Nucleotides, 1999
- Synthesis of Oligonucleotides Bearing Polyamine Groups for Recognition of DNA SequencesNucleosides and Nucleotides, 1999
- Antisense Oligonucleotide Conjugates with Photosensitizers-An UpdateNucleosides and Nucleotides, 1998
- Duplex Stabilization by DNA-Hoechst 33258 Conjugates: Effects of Base Pair MismatchesNucleosides and Nucleotides, 1998
- Cholesterol Conjugated Uniform and Gapmer Phosphorothioate Oligonucleotides Targeted Against PKC-α and C-rafGene ExpressionNucleosides and Nucleotides, 1997
- Concept, Discovery and Development of MMI Linkage: Story of a Novel Linkage: for Antisense ConstructsNucleosides and Nucleotides, 1997
- The Chemistry of C-Branched Spermine Tethered Oligo-DNAs and Their Properties in Forming Duplexes and TriplexesNucleosides and Nucleotides, 1997