THE STIMULATION AND PROLONGED MAINTENANCE OF SPERMATOGENESIS BY HUMAN PITUITARY GONADOTROPHINS IN A PATIENT WITH HYPOGONADOTROPHIC HYPOGONADISM

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Abstract
SUMMARY: The clinical course of a man with an apparently isolated deficiency of pituitary gonadotrophin is described. Despite interstitial cell stimulation, prolonged therapy with human chorionic gonadotrophin did not produce spermatogenesis. In contrast, 60 days after treatment with human pituitary gonadotrophin had started, viable spermatozoa were seen and spermatogenesis was subsequently maintained for 16 months. The sequence of changes observed supports the concept that the action of follicle-stimulating hormone in the testicular tubule is at a late stage of spermatozoa formation.