Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
- 1 September 1994
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 102 (suppl 3) , 31-33
- https://doi.org/10.1289/ehp.94102s331
Abstract
Chromium(VI) compounds are known to be potent toxic and carcinogenic agents. Because chromium(VI) is easily taken up by cells and is subsequently reduced to chromium(III), the formation of paramagnetic chromium such as chromium(V) and chromium(III) is believed to play a role in the adverse biological effects of chromium(VI) compounds. The present report, uses electron spin resonance (ESR) spectroscopy; the importance of the role of paramagnetic chromium in chromium(VI)-induced damage in intact cultured cells is discussed, based upon our studies with antioxidants including vitamin E (alpha-tocopherol), B2 (riboflavin), C (ascorbic acid), and so on. These studies appear to confirm the participation of paramagnetic Cr such as chromium(V) and Chromium(III) in chromium(VI)-induced cellular damage.Keywords
This publication has 28 references indexed in Scilit:
- Potentiation of sodium chromate(VI)-induced chromosomal aberrations and mutation by vitamin B2 in Chinese hamster V79 cellsMutation Research Letters, 1992
- EFFECT OF VITAMIN E ON CYTOTOXICITY, DNA SINGLE STRAND BREAKS, CHROMOSOMAL ABERRATIONS, AND MUTATION IN CHINESE HAMSTER V‐79 CELLS EXPOSED TO ULTRAVIOLET‐B LIGHTPhotochemistry and Photobiology, 1992
- Effects of vitamins on chromium(VI)-induced damage.Environmental Health Perspectives, 1991
- Reaction of chromium(VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damageChemical Research in Toxicology, 1990
- In vitro interaction of mutagenic chromium(VI) with red blood cellsFEBS Letters, 1989
- Chromium(V)-induced cleavage of DNA: are chromium(V) complexes the active carcinogens in chromium(VI)-induced cancers?Chemical Research in Toxicology, 1989
- Vitamin B2-enhancement of sodium chromate (VI) — Induced DNA single strand breaks: ESR study of the action of vitamin B2Biochemical and Biophysical Research Communications, 1989
- On the mechanism of the chromate reduction by glutathione: ESR evidence for the glutathionyl radical and an isolable Cr(V) intermediateBiochemical and Biophysical Research Communications, 1988
- Effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by sodium chromate (VI)Cancer Letters, 1987
- Intracellular chromium reductionBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1987