Gastric juice electrolyte secretion in conscious dogs with gastric fistulae and its modification by FPL 52694, a mast cell stabilizing agent

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Abstract
1 Studies have been made of the electrolyte output in the gastric juice of conscious dogs equipped with gastric fistulae during stimulation by intravenous infusion of either pentagastrin (2 μg kg−1 h−1), histamine (30 μg kg−1 h−1) or insulin (0.1 u kg−1 h−1). 2 The mast cell stabilizing agent, FPL 52694 (4.35 mg ml−1) was instilled into the stomach for 30 min and caused a marked reduction of H+ output, H+ concentration and osmotic strength of the juice during stimulation with pentagastrin, histamine, or insulin. There was also a marked increase in the rate of Na+ output into the juice. 3 When pentagastrin-stimulated acid secretion was inhibited by cimetidine (4 μmol kg−1 i.v.) acid output was reduced but there were no sustained changes in ion concentrations, osmolality or Na+ output of the type seen following inhibition with FPL 52694. 4 It is concluded that FPL 52694 may have a dual mode of action in this preparation; a direct reduction of the output of hydrochloric acid and a smaller effect to increase gastric NaHCO3 output leading to a post-secretory neutralization of the juice.