Structural Features of the Phosphoribosyl-Transferases and Their Relationship to the Human Deficiency Disorders of Purine and Pyrimidine Metabolis
- 1 January 1981
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Biochemistry
- Vol. 11 (1) , 1-34
- https://doi.org/10.3109/10409238109108698
Abstract
Similarities in the physical and chemical properties of the phosphoribosyltransferase family of enzymes suggest that they may share common structural features as observed in other functionally related proteins. The unusually high incidence of structural gene mutations of these enzymes in man are associated with several metabolic diseases of purine and pyrimidine metabolism. It is proposed that these disorders are the consequence of structural mutations to an architectural domain common to all of the phosphoribosyltransferases.Keywords
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