Effect of Species Differences of Mice on the Bio-as say of Thyrotropin

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Abstract
The McKenzie bio-assay for TSH was modified to permit the handling of large numbers of mice and the consequent analysis of many samples during a single assay run. An attempt was made to find a strain of mice significantly more sensitive to TSH than the Swiss-Webster albino (SWA) animals normally used. Twenty-two strains of inbred mice and 2 strains of deer mice (Peromyscus maniculalus) were tested. The results of the assays of the various strains of animals were computed with the aid of a digital computer. The relation between the logarithm of the responses to TSH and the doses of TSH was found to be the most useful index. The deer mice were insensitive to the doses of TSH used. Although some of the strains of inbred mice were found to be significantly more sensitive to TSH than the SWA controls, in no case was the increased sensitivity of the inbred mice sufficient to increase the usefulness of the assay. (Endocrinology76: 890, 1965)

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