25-Hydroxycholecalciferol 1α-Hydroxylase Activity in the Kidney of the Fetal, Neonatal and Adult Guinea Pig

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Abstract
Homogenates of fetal, newborn and maternal kidney and placenta have been compared with homogenates of non-pregnant adult kidney for their ability to hydroxylate 25- hydroxycholecalciferol. The activity in the fetal kidney near term is similar to that in the mother and 4–5 times that in the non-pregnant adult. These differences from the non-pregnant adult are significant (p < 0.05 and 0.1 fetus and newborn, respectively). Even higher levels are present in some newborn 12–24 h after birth, but these values fall towards the non-pregnant level in the following 21 days. Significant hydroxylating activity is present in the near-term placenta.

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