A possible effect of vitamin D metabolites on cell adhesion
- 1 January 1977
- journal article
- research article
- Published by Wiley in Cell Biology International Reports
- Vol. 1 (1) , 93-97
- https://doi.org/10.1016/0309-1651(77)90015-7
Abstract
The effect has been studied of the metabolites of vitamin D on the adhesion of 3T6 fibroblast cells and of pig aortic endothelial cells in culture. 1,25-dihydroxycholecalciferol (x10(-7)M) caused a decrease within 2 h in the adhesive qualities of the cells causing them to float free in the medium; the largest effect was seen with the endothelial cells. All the metabolites of vitamin D tested produced an effect including 25-hydroxyvitamin D which appeared to also have a major toxic effect on the endothelial cells.Keywords
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