Development of Potent Thrombin Receptor Antagonist Peptides
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 39 (25) , 4879-4887
- https://doi.org/10.1021/jm960455s
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- ‘Tethered ligand’derived pentapeptide agonists of thrombin receptor: a study of side chain requirements for human platelet activation and GTPase stimulationInternational Journal of Peptide and Protein Research, 1995
- Locating ligand-binding sites in 7tm receptors by protein engineeringCurrent Opinion in Biotechnology, 1994
- Side‐product formation during cyclization with HBTU on a solid supportInternational Journal of Peptide and Protein Research, 1994
- Enhancement of Thrombin Receptor Activation by Thrombin Receptor-Derived Heptapeptide with para-Fluorophenylalanine in Place of PhenylalanineBiochemical and Biophysical Research Communications, 1993
- The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation.Journal of Clinical Investigation, 1993
- Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H seriesJournal of Medicinal Chemistry, 1993
- Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.Journal of Clinical Investigation, 1993
- Structure-activity studies of the thrombin receptor activating peptideBiochemical and Biophysical Research Communications, 1992
- 1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesisThe Journal of Organic Chemistry, 1992
- A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cellsBiochemical and Biophysical Research Communications, 1991