Endothelial monocyte antigens in man.

  • 1 December 1978
    • journal article
    • Vol. 10  (4) , 875-7
Abstract
A group of antigens expressed in endothelial cells and monocytes, but not detectable in either T or B lymphocytes, has been the object of ongoing studies. The antibodies were not removed by absorption with platelets or B lymphocytes and were readily eliminated after absorption with monocytes or endothelial cells. Stripping with rabbit anti-human beta2-microglobulin made endothelial cells or monocytes resistant to lysis by endothelial-monocyte antibodies. Thus, endothelial monocyte antigens may be associated with beta2-microglobulin and are distinct from HLA-DR in this regard. Family studies suggest that most, but not all, monocyte-specific reactions segregated in linkage with HLA.

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