Decrease in Human Striatal Dopamine D2 Receptor Density with Age: A PET Study with [11C]Raclopride
- 1 March 1993
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 13 (2) , 310-314
- https://doi.org/10.1038/jcbfm.1993.39
Abstract
The effect of age on human striatal dopamine D2 receptors was investigated with positron emission tomography (PET) using [11C]raclopride as a radioligand. Twenty-one healthy volunteers aged from 20 to 81 years were studied. An equilibrium method was applied and two separate PET scans with different specific activities of [11C]raclopride were performed. The maximal number of receptors ( Bmax) and their dissociation constant ( Kd) were calculated using Scatchard analysis. There was an age-dependent decline in the Bmax ( r = 0.49; p = 0.02) of striatal D2 receptors while the Kd remained unchanged. The results show that there is an age-related loss of striatal D2 receptors, which, together with other changes in the brain nigrostriatal dopaminergic system, may contribute to extrapyramidal symptoms associated with aging.Keywords
This publication has 29 references indexed in Scilit:
- D2 Dopamine Receptors in Neuroleptic-Naive Schizophrenic PatientsArchives of General Psychiatry, 1990
- Age‐related changes in the human nigrostriatal dopaminergic systemAnnals of Neurology, 1990
- Kinetic Analysis of Central [11C]Raclopride Binding to D2-Dopamine Receptors Studied by PET—A Comparison to the Equilibrium AnalysisJournal of Cerebral Blood Flow & Metabolism, 1989
- Stereoselective binding of 11C-raclopride in living human brain ? a search for extrastriatal central D2-dopamine receptors by PETPsychopharmacology, 1988
- Human dopamine receptor subtypes?in vitro binding analysis using3H-SCH 23390 and3H-racloprideJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1988
- Dopamine receptor subtype imbalance in schizophreniaLife Sciences, 1987
- Loss of Striatal [76Br]Bromospiperone Binding Sites Demonstrated by Positron Tomography in Progressive Supranuclear PalsyJournal of Cerebral Blood Flow & Metabolism, 1986
- Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PETScience, 1986
- Central Dopaminergic Pathways in Hemiparkinsonism Examined by Positron Emission TomographyCanadian Journal of Neurological Sciences, 1984
- Neurologic Signs in Uncomplicated Aging (Senescence)Seminars in Neurology, 1981