Distribution of Dopamine in the rat cerebral cortex

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Abstract
The rat cerebral neocortex was sectioned by 3 transverse cuts and analyzed for dopamine and noradrenaline. Dopamine concentration decreased gradually from the rostral (97±4 ng/g) to the caudal (59±2 ng/g) end of the neocortex. Also, the noradrenaline concentration was highest in the rostral part (269±6 ng/g) and decreased gradually reaching a concentration of 238±3 ng/g in the caudal part. Since the quotient dopamine/ noradrenaline showed similar changes in the neocortex parts investigated the data support the view that dopamine serves as a transmitter in cortical neurons apart from being a precursor for noradrenaline.