THE EFFECT OF CORTICOTROPHIN AND CORTISONE ON NEUTRAL 17-KETOSTEROID METABOLISM AS DEMONSTRATED BY MICROCHROMATOGRAPHIC FRACTIONATION OF URINARY EXTRACTS FROM TWELVE TREATED PATIENTS

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Abstract
The effect of ACTH and cortisone on the neutral 17-ketosteroid excretion was investigated in 12 patients in whom adrenal function was either normal or very much reduced. ACTH produced a marked increase in the beta-fraction and the 11-oxy-17-ketosteroid fraction in patients with low adrenocortical activity. In patients with a normal adrenal function, the results were neither so striking nor so well marked. Giving 25-50 mg of cortisone daily produced a general depression of neutral 17-ketosteroid excretion and a rise of the 11-oxy-17-ketosteroid fraction, thus suggesting that cortisone was partly metabolized to this com-pound.