DNA Synthesis in Cartilage Cells Is Stimulated by Oscillating Electric Fields
- 10 February 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4329) , 690-692
- https://doi.org/10.1126/science.625660
Abstract
External oscillating electric fields (1166 volts per centimeter, 5 hertz) enhanced the incorporation of [ 3 H]thymidine into the DNA of chondrocytes isolated from the proliferative layer of embryonic (16 days) chick epiphysis. Verapamil or tetrodotoxin at 10 -6 M concentrations completely blocked the electric field effect. Tetracaine reduced the incorporation of [ 3 H]thymidine in both control and electrically stimulated cells. The findings support the hypothesis that Na + and Ca 2+ fluxes generated by the electrical perturbation trigger DNA synthesis in these cells.This publication has 39 references indexed in Scilit:
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