Sensitivity of different thromboplastin reagents to factor VII deficiency in the blood of beagle dogs

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Abstract
Differences in prothrombin time using various sources of tissue extract have been investigated in normal and factor VII-deficient beagles homozygous for the defect. All the tissue extracts tested gave a prolonged prothrombin time with factor VII-deficient plasma but the degree of difference from normal varied according to the source of the extract. Recommendations are made for screening dogs for the defect.

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