Mice with the xid defect have helper cells for T15 idiotype-dominant anti-phosphorylcholine primary and secondary plaque-forming cells responses.

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Abstract
The abilities of helper T cells from commercially available (CBA/N .times. BALB/c)F1 (NBF1) xid male and phenotypically normal female mice to help T15+ and T15- B cells to produce thymus-dependent phosphorylcholine (PC)-specific direct plaque-forming cell responses were examined. Carrier-primed T cells from both male and female mice restored T15+ thymus-dependent responses in congenitally athymic BALB/c mice, helped PC-primed BALB/c splenic B cells produce predominantly T15+ responses and provided help for T15+ and T15- plaque-forming cell responses generated by PC-primed normal F1 splenic B cells. Carrier-primed irradiated xid and normal recipients contributed adequate helper activity for T15 dominant responses. Male and female NBF1 mice apparently are equally capable of helping T15+ responses.